Product Details

17-AAG, 17-(Allylamino)-17-demethoxygeldanamycin (AGS-A1256)

Features

17-AAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells.


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17-AAG, 17-(Allylamino)-17-demethoxygeldanamycin [A1256]

 

Description: 17-AAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. 17-AAG binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins that require this chaperone for conformational maturation 17-AAG is a less toxic analogue of the geldanamycin.


Chemical Formula: C31H43N3O8
Chemical Name: : 17-(Allylamino)-17-demethoxygeldanamycin,
Molecular Weight: M.W. 585.7
Solubility: Soluble in DMSO or Methanol. Clear Purple solution at 10 mg / ml.
CAS Number: CAS [75747-14-7]
Active Product: Yes
Appearance: Purple Powder
Purity: >98%
Handling: Store in a tightly sealed vial. For use by trained professionals only. Research purposes only.
Storage: +4 deg C.

 

 

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