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(S)-Methyl-L-thiocitrulline.Dihydrochloride (AGS-M1012)



A potent, selective inhibitor of neuronal Nitric Oxide Synthase.

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(S)-Methyl-L-thiocitrulline.Dihydrochloride [M1012]


Description: A potent, selective inhibitor of neuronal Nitric Oxide Synthase.

Chemical Formula: C7H15N3O2S.2 HCl
Molecular Weight: M.W. 205.3
Solubility: Soluble in Water.
CAS Number: CAS [156719-39-0]
Active Product: N
Appearance: White Solid
Purity: >98%
Handling: Hygroscopic. Protect from Light and Moisture.
Storage: +4 deg C.

Literature Reference: 1. Narayanan, K., O.W. Griffith., Synthesis of L-Thiocitrulline, L-Homothiocitrulline, and S-Methyl-L-Thiocitrulline: A New Class of Potent Nitric Oxide Synthase Inhibitors., 1994., 37(7):, 885-887., 2. Furfine, E.S., et al..
Literature Reference: Potent and Selective Inhibition of Human Nitric Oxide Synthases. Selective Inhibition of Neuronal Nitric Oxide Synthase by S-Methyl-L-Thiocitrulline and S-Ethyl-L-Thiocitrulline., Journal of Biological Chemistry., 1994., 269(43):, 26677-26683., 3. Joly, G.A., K. Narayanan, O.W. Griffith, R.G. Kilbourn..
Literature Reference: Characterization of the Effects of Two New Arginine / Citrulline Analogs on Constitutive and Inducible Nitric Oxide Synthases in Rat Aorta., British Journal of Pharmacology., 1995., 115(3):, 491-497., 4. Zanzinger, J., J. Czachurski, H. Seller..
Literature Reference: Neuronal Nitric Oxide Reduces Sympathetic Excitability by Modulation of Central Glutamate Effects in Pigs., Circulation Research., 1997., 80(4):, 565-571..



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