Product Details

Erweka On-/Offline dissolution systems HPLC or UV/VIS (ERW-DIS-HPLC-UVVIS)

Erweka On-/Offline dissolution systems HPLC or UV/VIS


A high degree of automation and flexibility is offered by the new half-automated on-/offline dissolution system. It is based on the fully validated ERWEKA software and offers automated dissolution testing, fraction collection, UV-VIS or HPLC analysis as well a combination of all.

The on-/offline dissolution system uses an innovative flow-through system of sealed PEEK-vials. The sample is withdrawn from the dissolution vessel through tip filters from 1 µm porosity by a peristaltic pump.

In case of filtration from 0.45 µm porosity, the membrane filter changer AFC 825  or double filtration station in combination with the high-precision high pressure piston pump PVP 820 (filtration of 0.22 µm) can be used to the PEEK block of sealed flow-through vials integrated in the auto sampler.

Delivery time: 4-6 Weeks
Delivery times may vary
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A x/y/z driven arm with an embedded syringe picks up the samples from the flow-through vials and stores them into HPLC vials (max. 324 sealed vials; optionally electronically tempered from 4° to 70°). A time managing program optimizes and calculates when a sample can be transferred from the HPLC-Vials to the Rheodyne valve for HPLC analysis. A direct online injection without buffering the samples is also possible.

The auto sampler offers such features as multiple standard racks for HPLC device calibration, needle wash station, replacement of the withdrawn sample volume by fresh media.

HPLC Online connection or chromatograph systems
Our on-/offline dissolution system offers connection to equipment of all manufacturers of HPLC systems for e.g. Shimadzu, Agilent and Waters as well as the possibility of a connection to different chromatograph systems like Empower (Waters) or Cerity (Agilent).

UV-VIS Online Connection
In addition to the HPLC connection the ERWEKA on-/offline dissolution system offers the possibility to include a UV-VIS spectrophotometer (ERWEKA, Perkin Elmer, Shimadzu, Analytic Jena, Agilent) into the closed-loop sample withdrawal system, either between the sample transfer pump and the PEEK flow-through vial block or the PEEK flow-through vial block and the return to the dissolution tester.

Therefore the ERWEKA on-/offline dissolution system can be used as:

sample collection device (max. 324 samples; incl. sample tempering),
a HPLC online system in combination with virtually any brand of HPLC device,
an UV-VIS online system (incl. virtual dilution by various path length with optimized flow-through cuvettes).

Capacity - connect up to two dissolution testers

Off-/Online dissolution system with two dissolution testers DT 820
The ERWEKA on-/offline dissolution system allows to connect two ERWEKA dissolution testers via two individual sample transfer pumps to one Autosampler with two embedded PEEK flow-through vial blocks (no cross contamination).

Either none, one or both of the dissolution testers, in addition to the HPLC Online system, can be fitted with a UV-VIS spectrophotometer inside the close-loop sampling system.

Based on the ERWEKA standard dissolution software, the system enables the im-/export to other IT-systems for e.g. LIMS or chromatography data systems. Also the automatic recording of sampling times, temperature and rotation speed in each vessel brings facilitation. Every deviation is documented automatically.

Video monitoring

Dissolution system with DT 820 including video monitoring
An automated system runs without user observation. In order to determinate the cause in case of unexpected results, ERWEKA offers video monitoring of  six dissolution vessels of one or two connected dissolution testers.

The video monitoring allows recording of each test-run in combination with real-time overlapping dissolution profile to identify disturbances such as coning etc. and to get the visual impression of 24 hours in 2 minutes.

The video monitoring is a very powerful tool for method development as well for troubleshooting.

Dissolution Tester:

1x or 2x ERWEKA DT 820 or DT 720

Fraction Collection:

CTC Fraction Collector: up to 324 HPLC vials (optional cooled)


8-Channel Peristaltic Pump (IPC 8). Pump tubings are made of Verderprene (similar to fluoropolymer) to prevent the absorption previously associated with peristaltic pumps and PVC tubing. Via the serial RS 232 interface the pump is controlled from the external PC

Valve-free 8-channel piston pump PVP 820 (accuracy +/- 5%); for Dissolution Tester No. 1 or No. 2;

instead Peristaltic Pump


ERWEKA SPM, Perkin Elmer Lamda 25 or Shimadzu 1800 including 8 position cell changer, Dissolution Kit, additional tubing/connectors and upgraded validated HADs Dissolution software for Online UV-VIS analysis incl. protocols

Analytic Jena Specord 205 or Agilent 8453, including 8 position cell changer, dissolution kit, additional tubing/connectors and upgraded validated HADs dissolution software for Online UV-VIS analysis incl. protocols

System Control:

ERWEKA Software: Windows based, CFR 21/11 compliant.

ERWEKA driver to connect and control ERWKA DT dissolution testers

System Tubing/:


System tubing PTFE/preconfiguration


Brand name computer in minitower housing, operating system Windows XP, keyboard, mouse, monitor

High-Performance PC for use of HADs with Video monitoring system


Cuvettes for UV-VIS Spectrophotometers with fluoropolymer tubing (0.8 mm o.d.) and screwfittings are available with various path length (1 mm, 2 mm, 5 mm, 10 mm)


IQ/OQ/PV documents are available for all components on request

IQ/OQ/PV service is available


Video monitoring


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